It’s a bit complicated, both because some studies just asked people if they are ‘natural redheads’ and didn’t actually test whether they have the MCR1 mutation and because it depends on the mechanism of action of the drug. Some sedatives are less effective, so need higher doses, but the majority of opioid based pain control drugs require lower doses in redheads.
It’s a bit complicated, both because some studies just asked people if they are ‘natural redheads’ and didn’t actually test whether they have the MCR1 mutation and because it depends on the mechanism of action of the drug. Some sedatives are less effective, so need higher doses, but the majority of opioid based pain control drugs require lower doses in redheads.
https://www.nih.gov/news-events/nih-research-matters/study-finds-link-between-red-hair-pain-threshold